Convulsive seizures petit mal and grand mal have been reported, particularly in patients with EEG abnormalities or history of such disorders.
All Interactions Sort By: Subcutaneous injection is not advised. Some hyperprolactinemic women with normal menstruation may have an increased number of anovulatory cycles, which may result in subfertility.
Abnormality of the cerebrospinal fluid proteins has also been reported. Since they appear to be more susceptible to hypotension and neuromuscular reactions, such patients should be observed closely. Dosage and frequency of administration should be adjusted according to the severity of the symptoms and response of the patient.
According to the American Psychiatric Association treatment guidelines for schizophrenia, consider pregnancy testing in women of childbearing potential prior to initiation of an antipsychotic. Severe postural hypotension may occur with concomitant administration of chlorpromazine and ACE inhibitors. Lemon-yellow color does not alter potency. Hypothermia appears to occur more frequently during initiation of antipsychotic therapy or after dose increases.
The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic s of the patients is not clear. To control nausea and vomiting.
Do not exceed the following maximum daily dose limits: Intractable Hiccups — Oral: Should symptoms persist, use slow IV infusion with patient flat in bed: Brand and Other Names: If troublesome, dosage may be lowered.
Increases in appetite and weight sometimes occur. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. The syndrome can also develop, although much less frequently, after relatively brief treatment periods at low doses.
If hypotension does not occur, administer 25 to 50 mg IM every 3 to 4 hours as needed until vomiting stops, and then patients should be switched to oral formulations. The concomitant use of chlorpromazine with lithium, other QT prolongation agents, and dopaminergic antiparkinsonism agents is not recommended see Section 4.
An antipsychotic should generally be used only for the conditions listed in the guidelines e.
An encephalopathic syndrome characterized by weakness, lethargy, fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis, elevated serum enzymes, BUN and FBS has occurred in a few patients treated with lithium plus an antipsychotic. The signs of intestinal obstruction may be obscured by the anti-emetic action of chlorpromazine. According to the Beers Criteria, antipsychotics are considered potentially inappropriate medications PIMs in elderly patients, and use should be avoided except for treating schizophrenia or bipolar disorder, and for short-term use as antiemetics during chemotherapy.
Phenothiazines should not be administered to children of any age whose signs and symptoms are suggestive of Reye's syndrome. In a small number of cases, they have been reported to precede serious arrhythmias, including ventricular tachycardia and fibrillation, which have occurred after overdosage.