See My Options close. In addition, caution is recommended when administering clobazam with medications extensively metabolized by CYP2D6 such as diphenhydramine because clobazam has been shown to inhibit CYP2D6 in vivo and may increase concentrations of drugs metabolized by this enzyme.
Moderate Consider an alternative to diphenhydramine if antihistamine therapy is necessary in a patient receiving metoprolol. Consider alternative therapy to antihistamines where possible. Adults should be given approximately 50 percent of this dose initially.
Antihistamine overdosage reactions may vary from central nervous system depression to stimulation. The anticholinergic activity of H1-antagonists may result in thickened bronchial secretions in the respiratory tract thereby aggravating an acute asthmatic attack or chronic obstructive pulmonary disease COPD.
Apply gently to affected area. Sensitive persons may have similar reactions to NSAIDs antigenically unrelated to aspirin and must take only acetaminophen for mild pain or fever. Patients given the combination tend to have higher metoprolol plasma concentrations and greater pharmacodynamic effects from metoprolol.
The rationale is to reduce the risk of recurring or protracted anaphylaxis. Urticaria ZyrtecpromethazineloratadinecetirizineClaritindiphenhydramineMore The risks of death and severe nonfatal reactions with high-vs low-osmolality contrast media: Cobicistat; Elvitegravir; Emtricitabine; Tenofovir Alafenamide: Moderate If concurrent use of diphenhydramine and buprenorphine is necessary, consider a dose reduction of one or both drugs because of the potential for additive pharmacological effects.
Prior to concurrent use of oxymorphone in patients taking a CNS depressant, assess the level of tolerance to CNS depression that has developed, the duration of use, and the patient's overall response to treatment. Headache, rhinitis, substernal pain, pruritus, and seizure occur less frequently. Because diphenhydramine exhibits a significant amount of anticholinergic activity, the use of an H1-antagonist with less anticholinergic activity is preferable when therapy is indicated.
Minor Combined use of metoclopramide and other CNS depressants, such as anxiolytics, sedatives, and hypnotics, can increase possible sedation. The diagnosis and management of anaphylaxis.
Motion Sickness Treatment or prophylaxis: Intravenous access should be obtained for fluid resuscitation, because large volumes of fluids may be required to treat hypotension caused by increased vascular permeability and vasodilation.
For non-prescription self-treatment of cough caused by minor throat and bronchial irritation. Moderate Amphetamines may pharmacodynamically counteract the sedative properties of sedating H1-blockers. Urinary histamine levels remain elevated somewhat longer. Long-term studies in animals to determine mutagenic and carcinogenic potential have not been performed.
Anaphylaxis is a life-threatening reaction with respiratory, cardiovascular, cutaneous, or gastrointestinal manifestations resulting from exposure to an offending agent, usually a food, insect sting, medication, or physical factor. Major Concomitant use of rotigotine with other CNS depressants, such as diphenhydramine, can potentiate the sedation effects of rotigotine. Skin testing in the evaluation of hymenoptera allergy and drug allergy.
Theoretically, coadministration of hydrocodone and a CYP2D6 inhibitor, such as chlorpheniramine or diphenhydramine, may result in a reduction in the analgesic effect of hydrocodone.