The pharmacokinetics, efficacy and safety of Glimepiride tablets have been evaluated in pediatric patients with type 2 diabetes as described below. This drug may be used as part of a combination therapy. All Interactions Sort By: After 24 weeks, the overall mean treatment difference in HbA 1c between Glimepiride tablets and metformin was 0. Storage Store at room temperature away from light and moisture.
Glimepiride was non-mutagenic in a battery of in vitro and in vivo mutagenicity studies Ames test, somatic cell mutation, chromosomal aberration, unscheduled DNA synthesis, mouse micronucleus test. Adding plans allows you to compare formulary status to other drugs in the same class. Neither Everyday Health nor its licensor assume any responsibility for any aspect of healthcare administered with the aid of the information provided.
The primary mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells.
This fetotoxicity, observed only at doses inducing maternal hypoglycemia, is believed to be directly related to the pharmacologic hypoglycemic action of Glimepiride and has been similarly noted with other sulfonylureas.
Porphyria cutanea tarda, photosensitivity reactions, and allergic vasculitis have been reported with sulfonylureas, including AMARYL.
There were no significant differences in Glimepiride pharmacokinetics between the two age groups. Coadministration of either cimetidine mg once daily or ranitidine mg bid with a single 4-mg oral dose of AMARYL did not significantly alter the absorption and disposition of glimepiride, and no differences were seen in hypoglycemic symptomatology. Always carry your medication with you.
The safety and efficacy of AMARYL were evaluated in an active-controlled, single-blind patients onlyweek trial involving pediatric patients, ranging from 8 to 17 years of age, with Type 2 diabetes.
In rat reproduction studies, significant concentrations of glimepiride were observed in the serum and breast milk of the dams, as well as in the serum of the pups. These drugs can increase the effect of glimepiride and cause low blood sugar.
Your doctor may change your diabetes treatment during your pregnancy such as diet and medications including insulin. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, but greater sensitivity of some older individuals cannot be ruled out.
Allergy warning This drug is chemically similar to a class of medications called sulfonamides sulfa drugs.
Usual Geriatric Dose for Diabetes Type 2
A switch over from other oral hypoglycaemic agents to glimepiride can generally be done. While maintaining the metformin dose, the glimepiride therapy is started with a low dose, and is then titrated up depending on the desired level of metabolic control up to the maximum daily dose. Share cases and questions with Physicians on Medscape consult.
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Go to medicine cabinet. The use of insulin is required under such circumstances. I take metformin mg twice daily, Januvia mg once daily and glimepiride 6 mg once daily.
Risk related to the diabetes Abnormal blood glucose levels during pregnancy are associated with a higher incidence of congenital abnormalities and perinatal mortality.