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Loss of water from the cells results in an increase in the concentration of haemoglobin S and an increased risk of sickling. Hydroxyurea is not a cure for sickle cell disease so at present should be offered only to patients whose clinical condition is severe and who have been fully informed about this and other treatment options.
They learn about the different types of sickle cell disease and treatments, including blood transfusions and bone marrow transplants, and some of the promising new research in medicines and gene therapy. Patients receive oral hydroxyurea either once or twice daily plus oral clotrimazole twice daily after meals for 6 months.
While butyric acid can increase the body's production of fetal hemoglobin a protein found in infants that protects against sickle cellsnitric oxide and clotrimazole can prevent the development and bunching of existing sickle cells.
When employed, it should be undertaken early in the course of the disease before the onset of organ damage which reduces the chances of a success. Listing a study does not mean it has been evaluated by the U. Bone Marrow transplantation for Sickle cell disease. A bone marrow transplant may cure the disease; otherwise, treatment focuses on symptom management. You are using an outdated browser. Genetics Home Reference related topics: Common terms and phrases.
At appropriate doses, hydroxyurea and growth factors can increase the number of circulating stem cells in patients for later use in genetic manipulation.
Hydroxyurea enhances fetal hemoglobin production in sickle cell anemia. In future ,itmay become possible to treat the same group of patients with hydroxyurea complemented by gene therapy with minimal attendant risks March 25, Last Verified: Selected pages Title Page.
A mathematical model of the volume, pH, and ion content regulation in reticulocytes. As always, you should consult with your healthcare provider about your specific health needs.
It should not be used for medical advice, diagnosis or treatment.
The next decade will surely witness an interest in the genes and drugs which prevent membrane damage, cellular dehydration, regulate blood vessel integrity and flow. October 19, Last Update Posted: See All Health Guide. Didn't get the message?
Sickle cell anemia is a genetic disease of the blood. Augmentation by erythropoietin of the fetal-hemoglobin response to hydroxyurea in sickle cell disease. Combination therapy of erythropoietin, hydroxyurea, and clotrimazole in a beta thalassemic mouse: