Mode of action of fluoroquinolones.
View large Download slide. Applications of fluoroquinolones in biologic warfare are also discussed.
Mechanism of Action
Quinolone activity against anaerobes. The primary outcome was the proportion of patients who achieved sputum culture conversion after 3 months of treatment including trial drugs. Supplemental Content Full text links.
In vitro activity of Baya novel fluoroquinolone antimicrobial agent. This suggested that the similarity between the two groups is not caused by an insufficient number of participants, but by similar effectiveness between the two groups.
In vitro activity of moxifloxacin against Gram-positive bacteria. Portnoy; Comparative pharmacodynamics of moxifloxacin and levofloxacin in an in vitro dynamic model: The objective of the trial was to compare the effectiveness of LFX mg daily and MXF mg dailyplus the background drug regimen on culture conversion at 3 months of treatment.
Quinolones provide exceptional coverage against atypical pathogens when infection with these organisms is suspected in patients with community-acquired pneumonia. After reviewing the results of the interim analysis, the Data and Safety Monitoring Board recommended stopping enrollment after the interim analysis because there was little possibility of getting different results even after the target number of patients was fulfilled and it would take 3 or more years to finish the trial, which can undermine the validity of the results.
With definitions, cure was achieved in 54 patients We previously showed that the choice of levofloxacin or moxifloxacin for the treatment of patients with fluoroquinolone-sensitive multidrug-resistant tuberculosis MDR-TB did not affect sputum culture conversion at 3 months of treatment. All Accepts Healthy Volunteers: Adverse drug reactions were reported in six patients 7. When taken for four to six weeks, norfloxacin, ciprofloxacin, levofloxacin, and ofloxacin have eradication rates of 67 to 91 percent.
For patients Home Contact Us Cookies Policy. Moxifloxacin BAY has been studied extensively using in vitro dynamic models 1— 8 but only four studies 3, 5— 7 were comparative. In addition, the time to culture conversion was compared between the two groups. Int J Antimicrob Agents. In this prospective, multicenter, open-label, randomized controlled trial, 77 patients with mild-to-moderate community-acquired pneumonia with aspiration factors were enrolled and randomly assigned to receive moxifloxacin or levofloxacin plus metronidazole.
Stahlmann R, Lode H. Quinolones are well absorbed following oral administration, with moderate to excellent bioavailability. Choose a single article, issue, or full-access subscription.
Based on this pragmatic randomized controlled trial, we demonstrated that the effectiveness of LFX and MXF in terms of sputum culture conversion after 3 months of treatment of MDR-TB with other background drug regimens may be similar.