Misoprostol drug administration

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If this dose cannot be tolerated, a dose of mcg can be used. Oral misoprostol was given by asking the subject to take the tablets with water.

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This independent site has been set up to distribute dosage guidelines for the use of misoprostol in obstetrics and gynaecology. These problems usually occur during the first few weeks of treatment and stop after about a week. Tell your doctor right away if any of these unlikely but serious side effects occur: Misoprostol is widely used in obstetrics and gynaecology for medical abortion, cervical priming and induction of labour World Health Organization, ; El-Refaey et al.

Interactions See also the How to Use section. List Cytotec side effects by likelihood and severity. Diarrhea is common with misoprostol and usually occurs about two weeks after you start taking it, and lasts for about a week. Surgical termination of pregnancy was performed for the 40 subjects upon completion of the study. The area of each segment was computed according to the following formula for calculation of trapezium area: Cytotec has no clinically significant effect on the kinetics of diclofenac or ibuprofen.

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The following have been reported as adverse events in subjects receiving Misoprostol:. The following adverse events were infrequently reported. The blood samples were centrifuged and frozen in liquid nitrogen immediately. Cervical Ripening CytotecMore Adjustment of the dosing schedule in renally impaired patients is not routinely needed, but dosage can be reduced if the mcg dose is not tolerated see Clinical Pharmacology.

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The recommended adult oral dose of Misoprostol for reducing the risk of NSAID-induced gastric ulcers is mcg four times daily with food. Intrauterine fetal death f,g,1,5,6.

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An apparent response of the female mouse to Cytotec in long-term studies at to times the human dose was hyperostosismainly of the medulla of sternebrae. Misoprostol should not be used in cases where uterotonic drugs are generally contraindicated or where hyperstimulation of the uterus is considered inappropriate, such as cephalopelvic disproportion, grand multiparity, hypertonic or hyperactive uterine patterns, or fetal distress where delivery is not imminent, or when surgical intervention is more appropriate.

In countries where abortion is highly restricted by law, hospital personnel may be required to report all induced abortion attempts to legal authorities. It should be noted that there was a wide individual variability in the absorption of vaginal misoprostol with the addition of water. Related articles in Web of Science Google Scholar. Close inspection of the sanitary pad or other receptacle may reveal whether the pregnancy has been terminated.

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In most cases these problems develop during the first few weeks of therapy and stop after about a week. This may explain the inconsistent clinical effects of adding water to the tablet. The data in this study show that sublingual and oral administration have the quickest onset of action when compared with vaginal administration with or without water.

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