Possible explanations for the interface dermatitis on the back and knees in Patient 1 include the high dose of methotrexate, the increased epidermal thickness of the areas involved with concomitant increased epidermal proliferation albeit to a lesser extent then acral or mucosal skinthe patient's dependent position on his back during methotrexate administration, and the increased prevalence and extent of interface dermatitis in eruptions in patients with the acquired immunodeficiency syndrome [ 16 ].
When to call your doctor or health care professional about skin reactions: Maximum effects are generally achieved within 5 to 6 months, depending on dose escalation. If you are female, you will need to take a pregnancy test before you begin taking methotrexate.
Typically described as reddish patches covered with large dry silvery scales. A condition characterized by bleeding under the skin or mucous membranes.
Cerebral edema [ Ref ].
Megaloblastic anemia Very rare less than 0. If you are having an operation with a general anaesthetic, tell the anaesthetist you are on methotrexate.
For the Consumer
Renal insufficiency usually with high dosessevere nephropathy [ Ref ]. Have you read this leaflet? Like methotrexate, antibiotics that contain the drug trimethoprim or sulfonamides eg cotrimoxazole antagonise folate. Biopsies of each area revealed interface dermatitis with necrotic keratinocytes with an infiltrate of perivascular lymphocytes.
Notify your doctor if these symptoms develop before you take the next dose of methotrexate. Methotrexate may cause damage to the lining of your mouth, stomach, or intestines.
Methotrexate-induced papular eruption in patients with rheumatic diseases: A rash is a general term for skin reactions, some more specific terms are used to describe what the rash looks like such as:.
Def' related to MTX. Ointments are designed to be a barrier and stay on the surface of the skin for protection against harsh elements.
Patatanian E, Thompson DF. This is more commonly due to other reasons such as fatty liver, diabeteshyperlipidaemia, and obesity ie metabolic syndromebut can also develop from viral hepatitis and alcohol. If you have any concerns with your skin or its treatment, see a dermatologist for advice. This can occur as an overall darkening of the skin, or it can be localized.
Vertigo, confusion, seizures, convulsion, encephalopathy Very rare less than 0. Because of this, all drug-associated rashes should be reported to your health care professional for evaluation.