Arava 20 mg tablet

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If you forget to take a dose, take it as soon as you remember, unless it is nearly time for your next dose. Each tablet contains 20 mg of leflunomide.

Tell your doctor if you have a history of liver disease or if you also use other medicines such as: While this interaction is not expected to adversely impact the efficacy of oral contraceptives, consideration should be given to the type of oral contraceptive treatment. Text only version for the visually impaired Below is a text only representation of the Patient Information leaflet.

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If you are affected, do not drive, or use machines. Reliable contraception during treatment with leflunomide should also be guaranteed. For other substrates of BCRP e. Waiting period A plasma levels can be expected to be above 0.

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It is not known whether this medication affects the sperm. Arava 20 mg tablet. For hard copies please contact our medical information department at or email uk-medicalinformation sanofi.

What is Arava?

The metabolic biotransformation of leflunomide to A and subsequent metabolism of A is not controlled by a single enzyme and has been shown to occur in microsomal and cytosolic cellular fractions. From the results it can be concluded that efficacy results of the 20 mg maintenance dose were more favourable, on the other hand, the safety results favoured the 10 mg daily maintenance dose.

In human plasma, A is extensively bound to protein albumin. Lactose Arava contains lactose. Certain risk materials on this website are intended for use by healthcare professionals only.

It is known that medicinal products with immunosuppressive properties - like leflunomide - may cause patients to be more susceptible to infections, including opportunistic infections.

Healthcare professionals are asked to report any suspected adverse reactions via. Store at room temperature away from light and moisture.

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Consult your pharmacist or local waste disposal company. Improvement from baseline in the individual components of the ACR responder criteria was also sustained in most patients during the second year of Arava treatment in all three trials. General disorders and administration site conditions. No clinical data are available on the efficacy and safety of vaccinations under leflunomide treatment.

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Without receiving this drug elimination procedure, leflunomide could stay in your body for up to 2 years. Store in the original package. The leflunomide treatment effect was evident by 1 month, stabilised by 3 to 6 months and continued throughout the course of treatment.

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In a carcinogenicity study in rats, leflunomide did not show carcinogenic potential. If such effects occur, a washout see below to reduce plasma levels of A should be considered. The risk associated with combination therapy, in particular in long-term treatment, is unknown.